2(3H)-Furanone, 3-[2-[(1R,4aS,5R,6R,8aS)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4-hydroxy-, (3Z,4S)-
Andropanolide
CAS: 869807-57-8
Molecular Formula: C20H30O5
2(3H)-Furanone, 3-[2-[(1R,4aS,5R,6R,8aS)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4-hydroxy-, (3Z,4S)- - Names and Identifiers
2(3H)-Furanone, 3-[2-[(1R,4aS,5R,6R,8aS)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4-hydroxy-, (3Z,4S)- - Physico-chemical Properties
| Molecular Formula | C20H30O5 |
| Molar Mass | 350.45 |
| Density | 1.21±0.1 g/cm3(Predicted) |
| Melting Point | 210-211 °C(Solv: methanol (67-56-1)) |
| Boling Point | 557.3±50.0 °C(Predicted) |
| Specific Rotation(α) | ?31.5 (c, 0.5 in Py) |
| pKa | 12.36±0.20(Predicted) |
| Storage Condition | 2-8℃ |
2(3H)-Furanone, 3-[2-[(1R,4aS,5R,6R,8aS)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4-hydroxy-, (3Z,4S)- - Reference Information
| Plant Source: | Andrographis paniculata |
| biological activity | Andrographolide (Andro) andrographolide is a small antagonist that affects NF-κB activity by covalently modifying cysteine 62 of p50. Andrographolide (Andro) Andrographolide is a bicyclic diterpene lactone, mainly produced by Andrographis paniculate. Andrographolide (Andro) inhibits the activation of NF-κB in stimulated endothelial cells and reduces the expression of cell adhesion molecule E-selectin, E-selectin-mediated leukocyte adhesion was prevented but had no effect on IκBα degradation, p50 and p65 nuclear translocation. |
| Cell Line: | 293 cells |
| Concentration: | 15 μM |
| Incubation Time: | 12 hours |
| Result: | Inhibited NF-κB activation induced by TNF-α. |
Last Update：2024-04-09 22:09:11
![2(3H)-Furanone, 3-[2-[(1R,4aS,5R,6R,8aS)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4-hydroxy-, (3Z,4S)-](http://res.chembk.com/assets/str/2d/8/86/869807-57-8.png)
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